Evaluation of the toxicity of psychoactive compounds with the battery of bioassays was written by Nalecz-Jawecki, Grzegorz;Kaza, Michal;Sawicki, Jozef. And the article was included in Fresenius Environmental Bulletin in 2008.Formula: C21H27ClN2S2 This article mentions the following:
The toxicity of 14 psychoactive pharmaceuticals: antidepressants with two modes of action and antipsychotics were evaluated with the battery of six bioassays. Spirostomum ambiguum, Brachionus calyciflorus, and Thamnocephalus platyurus were more sensitive to the tested drugs than Tetrahymena thermophila, luminescent bacteria and the duckweed. In the first three tests the 24h-LC50’s ranged from 0.3 to 4.0 mg 1-1. In each test the toxicity data were homogenous within one order of magnitude except for the Microtox. N-demethylated derivatives norfluoxetine, desipramine, nortriptyline and norclomipramine were more toxic than the parent compounds Toxicity of the tested drugs strongly depended on the pH of water. At pH 5.5 the toxicity of the drugs in Spirotox was 2-5 folds lower than the toxicity at pH of 7.2 and 8.0. In the experiment, the researchers used many compounds, for example, Thioridazine hydrochloride (cas: 130-61-0Formula: C21H27ClN2S2).
Thioridazine hydrochloride (cas: 130-61-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Formula: C21H27ClN2S2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem