Basicity of piperidine derivatives and transmission of polar effects through piperidine ring. IV was written by Sokolova, T. D.;Bogatkov, S. V.;Malina, Yu. F.;Unkovskii, B. V.;Cherkasova, E. M.. And the article was included in Reaktsionnaya Sposobnost Organicheskikh Soedinenii in 1969.Safety of 1-(1-Methylpiperidin-4-yl)ethanone This article mentions the following:
The pKa of I and some other amines were determined potentiometrically in 1:1 H2O-MeOH by volume (R or amine and pKa are given): HOCH2, 9.29 卤 0.02; Ac, 8.64 卤 0.03; MeO2C, 8.51 卤 0.02; AcO, 8.35 卤 0.02; CN, 7.53 U 0.02; PhCH2CH2NEt2, 9.55 卤 0.02; Ph(CH2)3NMe2, 9.34 卤 0.01; 1-benzylpiperidine, 9.06 卤 0.02; PhCH2CH2NMe2, 9.01 卤 0.02; Ph-CH2NMe2, 8.71 卤 0.02; 4-methylmorpholine, 7.24 卤 0.02. The former values were correlated with inductive constants of equatorial substituents: pKa = (9.57 卤 0.09) – (1.5 卤 0.1)-未*RCH2; r = 0.981; s = 0.12; and the latter with 危未*: pKa = (9.29 卤 0.06) – (3.0 卤 0.2)危未*; r = 0.994; s = 0.10. Transmission coefficient of piperidine ring Z* = 0.45 卤 0.06 is independent of the solvent used (the above mixture, MeOH, PhNO2) and is higher than Z* = 0.30 of simple chains with 未 bonds. In the experiment, the researchers used many compounds, for example, 1-(1-Methylpiperidin-4-yl)ethanone (cas: 20691-91-2Safety of 1-(1-Methylpiperidin-4-yl)ethanone).
1-(1-Methylpiperidin-4-yl)ethanone (cas: 20691-91-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Safety of 1-(1-Methylpiperidin-4-yl)ethanone
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem