Ultra-trace level voltammetric sensor for MB in human plasma based on a carboxylic derivative of Calix[4]resorcinarene capped silver nanoparticles was written by Rehman Umar, Abdul;Hussain, Kashif;Aslam, Zara;Anwar Ul Haq, Muhammad;Muhammad, Haji;Sirajuddin;Raza Shah, Muhammad. And the article was included in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2022.Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine This article mentions the following:
This work was initiated by synthesizing a carboxylic derivative of Calix[4]resorcinarene through a three step protocol confirmed by proton NMR (1H NMR) spectroscopy and Electrospray ionization mass spectroscopy (ESI-MS). As synthesized derivative, was used as reducing and capping material for the fabrication of small and stable silver nanoparticles (AgNPs) in aqueous medium under the combined influence of dilute alkali and heat at 90° C. These nanoparticles were referred as KM20-AgNPs. Techniques used for characterization of AgNPs include UV-Visible (UV-Vis) spectroscopy, Fourier transform infra-red (FTIR) spectroscopy, at. force microscopy (AFM), dynamic light scattering (DLS) and zeta potential analyzer (ZPA). The finally produced KM20-AgNPs were recognized as highly sensitive and extremely selective voltammetric sensor for low level detection of methylene blue drug in the linear working range of 1-30 nM with limit of detection (LOD) and limit of quantification (LOQ) as 0.16 nM and 0.53 nM resp. The developed sensor was successfully used for sensing of MB in human blood plasma. In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine).
10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem