Moi, Davide et al. published their research in Molecules in 2022 | CAS: 1126-09-6

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Recommanded Product: 1126-09-6

Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity was written by Moi, Davide;Deplano, Alessandro;Angeli, Andrea;Balboni, Gianfranco;Supuran, Claudiu T.;Onnis, Valentina. And the article was included in Molecules in 2022.Recommanded Product: 1126-09-6 This article mentions the following:

Here, we report a small library of hydrazinocarbonyl-ureido and -thioureido benzenesulfonamide derivatives, I [R = Ph, C6H11, PhCH2, etc., X = O, S], that were designed and synthesized as potent and selective human carbonic anhydrase inhibitors (hCAIs). The synthesized compounds were ev=aluated against isoforms hCA I, II, IX and XII using acetazolamide (AAZ) as standard inhibitor. Several urea and thiourea derivatives showed inhibitory activity at low nanomolar levels with selectivity against the cytosolic hCA II isoform, as well as the transmembrane, tumor-associated enzymes hCA IX and XII. The thiourea derivatives showed enhanced potency as compared to urea analogs. Addnl., eight compounds, I [R = 3-FC6H4, 2,6-Me2C6H3, 2-MeOC6H4, 4-MeOC6H4, X = O, S], were selected for docking anal. on isoform I, II, IX, XII to illustrate the potential interaction with the enzyme to better understand the activity against the different isoforms. In the experiment, the researchers used many compounds, for example, Ethyl piperidine-4-carboxylate (cas: 1126-09-6Recommanded Product: 1126-09-6).

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Recommanded Product: 1126-09-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem