Dopaminergic activity in a series of N-substituted 2-aminopyrimidines was written by Moragues, J.;Prieto, J.;Spickett, R. G. W.;Vega, A.;Salazar, W.;Roberts, D. J.. And the article was included in Farmaco, Edizione Scientifica in 1980.Category: piperidines This article mentions the following:
Twenty-four title compounds, most of the structure I (R and R1 = H or Me; R2 = H, Cl, or OMe; R3 = H, Cl, Me, or OMe; or R2R3 = OCH2O), were synthesized and tested for pharmacol. activity associated with stimulation of central and peripheral dopamine receptors using piribedil as the reference standard Most of the new compounds had some degree of dopaminergic activity although in many cases central activity was not accompanied by peripheral activity and vice versa. Structure-activity relations were not apparent, and none of the new compounds possessed dopamine receptor blocking properties. In the experiment, the researchers used many compounds, for example, 1-(4-Methoxybenzyl)piperidin-4-amine dihydrochloride (cas: 57645-54-2Category: piperidines).
1-(4-Methoxybenzyl)piperidin-4-amine dihydrochloride (cas: 57645-54-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Category: piperidines
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem