Synthesis of new 4-substitued-1-(4-aminophenyl)-5,6-dihydropyridine-2(1H)-one sulfonamide conjugates and evaluation of their anti-microbial activity was written by Das, Tonmoy Chitta;Quadri, Syed Aziz Imam;Farooqui, Mazahar. And the article was included in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 2019.Application of 38560-30-4 This article mentions the following:
A new series of substituted sulfonyloxopyridine conjugates I (R = morpholin-4-yl, N-methylpiperazin-4-yl; R1 = Me, Et, CF3, Ph, 2-naphthyl, 4-MeC6H4; R2 = H, CF3) are reported for first time. The antibacterial and antifungal activities of the synthesized compounds I have been evaluated against known bacterial strains. The obtained data indicated that in particular, compound I (R = morpholin-4-yl, R1 = Ph, R2 = H) exhibited activity comparable to the well known antibacterial agents. The previously reported expensive and delicate processes for synthesis of 1-(4-nitrophenyl)piperidine-2-one have also been replaced with novel and efficient processes via lactam ring activation. In the experiment, the researchers used many compounds, for example, 1-(4-Nitrophenyl)piperidin-2-one (cas: 38560-30-4Application of 38560-30-4).
1-(4-Nitrophenyl)piperidin-2-one (cas: 38560-30-4) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Application of 38560-30-4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem