An efficient synthesis of N-arylated, orthogonally protected racemic aspartates was written by Luo, Guanglin;Chen, Ling;Civiello, Rita;Dubowchik, Gene M.. And the article was included in Tetrahedron Letters in 2008.Recommanded Product: 171049-35-7 This article mentions the following:
A brief and efficient synthesis of variously N-arylated racemic aspartates has been achieved by two consecutive reactions in one-pot, in which imine or equivalent, formed in situ from various anilines and Et glyoxylate, reacted with the Reformatsky reagent, tert-Bu 2-bromozinc acetate. Notably the two esters are orthogonally protected for the convenience of further derivatization. In the experiment, the researchers used many compounds, for example, tert-Butyl [4,4′-bipiperidine]-1-carboxylate (cas: 171049-35-7Recommanded Product: 171049-35-7).
tert-Butyl [4,4′-bipiperidine]-1-carboxylate (cas: 171049-35-7) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Recommanded Product: 171049-35-7
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem