Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents was written by Young, J. R.;Huang, S. X.;Chen, I.;Walsh, T. F.;DeVita, R. J.;Wyvratt, M. J.;Goulet, M. T.;Ren, N.;Lo, J.;Yang, Y. T.;Yudkovitz, J. B.;Cheng, K.;Smith, R. G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Category: piperidines This article mentions the following:
A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (I) was found to be optimal. In the experiment, the researchers used many compounds, for example, (S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2Category: piperidines).
(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Category: piperidines
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem