Synthesis of substituted 1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridines was written by Wolinska, Ewa;Paliakov, Ekaterina;Strekowski, Lucjan. And the article was included in Heterocyclic Communications in 2006.Computed Properties of C7H13NO This article mentions the following:
Synthesis of the substituted compounds I (2-Me or 2-Et; 6-H, 6-OMe or 6-OH; 10-NHR) is reported. This report pertains to the synthesis of 1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridines as potential immunosuppressive agents. As can be seen, the mols. I are substituted quinolin-4-amines, the N1 atom of which is basic (pKa > 7) due to conjugation of the N atom with the quinoline. Addnl. basic centers are parts of the side chain and the fused aliphatic ring. Derivatives of I contain a polar methoxy or hydroxy group. In the experiment, the researchers used many compounds, for example, 1-Ethylpiperidin-4-one (cas: 3612-18-8Computed Properties of C7H13NO).
1-Ethylpiperidin-4-one (cas: 3612-18-8) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Computed Properties of C7H13NO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem