N’Goka, Victor et al. published their research in European Journal of Medicinal Chemistry in 2004 | CAS: 85375-15-1

SKF-89976A Hydrochloride (cas: 85375-15-1) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Application In Synthesis of SKF-89976A Hydrochloride

Synthesis and GABA uptake inhibitory properties of 6-aryl iminoxymethyl substituted nipecotic acids was written by N’Goka, Victor;Stenbol, Tine B.;Krogsgaard-Larsen, Povl;Schlewer, Gilbert. And the article was included in European Journal of Medicinal Chemistry in 2004.Application In Synthesis of SKF-89976A Hydrochloride This article mentions the following:

Nipecotic acid derivatives, I [R1 = Ph, 4-PhC6H4, 2-MeC6H4; R2 = Ph, 2-MeC6H4, H, 2-ClC6H4, 伪-thienyl; R1R2 = fluorenyl, dibenzosuberyl; R3 = H, Et], bearing an aryl iminoxymethyl side chain at the position 6 were synthesized and tested for their GABA uptake inhibitory properties. Contrarily to the N-substituted derivatives, the introduction of the oxime function in the side chain of analogs of the active nipecotic derivative does neither increase, nor maintain the activity. In the experiment, the researchers used many compounds, for example, SKF-89976A Hydrochloride (cas: 85375-15-1Application In Synthesis of SKF-89976A Hydrochloride).

SKF-89976A Hydrochloride (cas: 85375-15-1) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Application In Synthesis of SKF-89976A Hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem