Total Synthesis of (-)-Senepodine G and (-)-Cermizine C was written by Snider, Barry B.;Grabowski, James F.. And the article was included in Journal of Organic Chemistry in 2007.Category: piperidines This article mentions the following:
An efficient, stereospecific synthesis of the alkaloids senepodine G chloride(I) and cermizine C (II) has been completed using the BF3路Et2O-promoted stereospecific addition of Me2CuLi to an 伪,尾-unsaturated lactam, the addition of MeMgBr followed by HCl to give senepodine G (six steps, 40% overall yield), and the stereospecific NaBH4 reduction of I to give cermizine C (seven steps, 40% overall yield). In the experiment, the researchers used many compounds, for example, (S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2Category: piperidines).
(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem