Formulation and evaluation of mouth dissolving tablet of fexofenadine hydrocloride was written by Talsaniya, Mahendra B.;Dabhi, Mahesh R.;Sheth, Navin R.;Dudhrejiya, Ashvin V.. And the article was included in Pharma Science Monitor in 2017.Reference of 153439-40-8 This article mentions the following:
The purpose of current study was to enhance the solubility and dissolution rate of fexofenadine HCl by co-grinding with different diluents. Simplex lattice design was utilized in the present study. The amount of diluent- X1 (D-mannitol), X2 (lactose), X3 (MCC) were selected as independent variables. Average particle size (Y1), saturation solubility (Y2) and the amount of drug release in 5 min (Y3) were taken as the responses. In each diluent mixture, appropriate amount of fexofenadine HCl mixed. These mixtures were co-ground by ball mill for two different time intervals (3hrs and 6hrs). Prepared phys. mixtures and various co-ground mixtures were evaluated for different densities, flow property, average particle size, drug content, saturation solubility, in vitro dissolution study. From the results co-ground mixture ABII (D-mannitol, lactose and drug co ground for 6 h) was found to be optimized. FTIR and DSC study shows that there was no any interaction between drug and excipients. Contour plot, overlay contour and response surface plot of the variables were prepared by statistic-7. Mouth Dissolving Tablet of optimized co-ground mixture was prepared by direct compression method using sucralose as sweetener and crospovidone as superdisintegrant. Prepared MDTs were evaluated for different pre-compression parameters and different post-compression parameters. All evaluation parameters were passed by prepared MDTs. There was enhancement of solubility of fexofenadine HCl and dissolution rate thus the MDTs shown faster release. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Reference of 153439-40-8).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Reference of 153439-40-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem