Recyclable Copper-Catalyzed Decarboxylative C-C Coupling of the sp3-Hybridized Carbon Atoms of α-Amino Acids was written by Zhao, Ruonan;Li, Jianying;Huang, Bin;Cai, Mingzhong. And the article was included in Catalysis Letters.Computed Properties of C13H17NO2 This article mentions the following:
A highly efficient heterogeneous copper(I)-catalyzed decarboxylative C-C coupling of α-amino acids with various carbon nucleophiles has been developed that proceeds smoothly in toluene at 110 °C by using an 2-aminoethylamino-modified SBA-15-supported copper(I) bromide complex as the catalyst and di-tert-Bu peroxide as the oxidant and provides a novel and practical approach for the synthesis of diverse propargylamines ArCH2N(R1)CH(R2)C=CR3 [Ar = Ph, 4-MeC6H4, 4-FC6H4, etc., R1R2 = CH2CH2CH2, CH2(CH2)2CH2, R3 = n-hexyl, Ph, 2-thienyl, etc.], (PhCH2)2NCH2CCPh, and ArCH2N(R1)CH(R2)X [Ar = Ph, 4-MeC6H4, 4-ClC6H4, X = CH2NO2, 3-indolyl, 5-chloro-2-indolyl, etc.] in good yields. The new heterogeneous copper(I) catalyst can be facilely prepared from com. easily available and inexpensive reagents via a simple procedure and exhibits a slightly higher catalytic activity than homogeneous CuBr/TMEDA system and can be recycled at least 8 times without any apparent loss of catalytic efficiency. In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidine-2-carboxylic acid (cas: 21319-53-9Computed Properties of C13H17NO2).
1-Benzylpiperidine-2-carboxylic acid (cas: 21319-53-9) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Computed Properties of C13H17NO2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem