With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20845-34-5,1-Methyl-2-piperidinemethanol,as a common compound, the synthetic route is as follows.
1-Methyl-2-piperidinemethanol (0.261 g, 2.02 mmol) was dissolved in 1,2-dimethoxyethane (6.00 mL), and the solution was mixed with a solution of n-butyllithium in hexane (1.60 mol/L, 1.30 mL, 2.08 mmol) added dropwise under ice-cooling. After stirring for fifteen minutes, the reaction mixture was mixed with 2-chloro-4-(2,4-dichlorobenzylamino)-6-(cyclopropylcarbonyl) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine prepared according to Process Steps 1 and 2 of Example 1 (0.205 g, 0.498 mmol), followed by stirring at 100¡ã C for three days. After checking the completion of the reaction by thin layer chromatography, the reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate_triethylamine=10:1) and thereby yielded Compound 3-27 (0.190 g, 76percent).
As the paragraph descriping shows that 20845-34-5 is playing an increasingly important role.
Reference£º
Patent; KYOWA HAKKO KOGYO CO., LTD.; EP1552842; (2005); A1;,
Piperidine – Wikipedia
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