Identification of a novel series of selective 5-HT7 receptor antagonists was written by Forbes, Ian T.;Cooper, David G.;Dodds, Emma K.;Douglas, Sara E.;Gribble, Andrew D.;Ife, Robert J.;Lightfoot, Andrew P.;Meeson, Malcolm;Campbell, Lorraine P.;Coleman, Tanya;Riley, Graham J.;Thomas, David R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Application In Synthesis of 4-(4-Fluorophenoxy)piperidine This article mentions the following:
Novel 5-HT7 receptor antagonists containing the benzocycloheptanone core were identified from high throughput screening. Mol. modeling and SAR studies have converted these intractable hits into a more potent, selective and tractable series, exemplified by compound I, SB-691673. In the experiment, the researchers used many compounds, for example, 4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3Application In Synthesis of 4-(4-Fluorophenoxy)piperidine).
4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application In Synthesis of 4-(4-Fluorophenoxy)piperidine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem