Guthrie, David B. et al. published their research in ACS Medicinal Chemistry Letters in 2012 | CAS: 163438-09-3

(R)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid (cas: 163438-09-3) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Electric Literature of C11H19NO4

Water-Soluble Progesterone Analogues Are Effective, Injectable Treatments in Animal Models of Traumatic Brain Injury was written by Guthrie, David B.;Stein, Donald G.;Liotta, Dennis C.;Lockwood, Mark A.;Sayeed, Iqbal;Atif, Fahim;Arrendale, Richard F.;Reddy, G. Prabhakar;Evers, Taylor J.;Marengo, Jose R.;Howard, Randy B.;Culver, Deborah G.;Natchus, Michael G.. And the article was included in ACS Medicinal Chemistry Letters in 2012.Electric Literature of C11H19NO4 This article mentions the following:

After more than 30 years of research and 30 failed clin. trials with as many different treatments, progesterone is the first agent to demonstrate robust clin. efficacy as a treatment for traumatic brain injuries. It is currently being investigated in two, independent phase III clin. trials in hospital settings; however, it presents a formidable solubility challenge that has so far prevented the identification of a formulation that would be suitable for emergency field response use or battlefield situations. Accordingly, we have designed and tested a novel series of water-soluble analogs that address this critical need. We report here the synthesis of C-20 oxime conjugates of progesterone as therapeutic agents for traumatic brain injuries with comparable efficacy in animal models of traumatic brain injury and improved solubility and pharmacokinetic profiles. Pharmacodynamic anal. reveals that a nonprogesterone steroidal analog may be primarily responsible for the observed activity. In the experiment, the researchers used many compounds, for example, (R)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid (cas: 163438-09-3Electric Literature of C11H19NO4).

(R)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid (cas: 163438-09-3) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Electric Literature of C11H19NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem