Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase was written by Eldrup, Anne B.;Soleymanzadeh, Fariba;Farrow, Neil A.;Kukulka, Alison;De Lombaert, Stephane. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Synthetic Route of C11H14FNO This article mentions the following:
Inhibition of sEH is hypothesized to lead to an increase in epoxyeicosatrienoic acids resulting in the potentiation of their anti-inflammatory and vasodilatory effects. In an effort to explore sEH inhibition as an avenue for the development of vasodilatory and cardio- or renal-protective agents, a lead identified through high-throughput screening was optimized, guided by the determination of a solid state co-structure with sEH. Replacement of potential toxicophores was followed by optimization of cell-based potency and ADME properties to provide a new class of functionally potent sEH inhibitors with attractive in vitro metabolic profiles and high and sustained plasma exposures after oral administration in the rat. In the experiment, the researchers used many compounds, for example, 4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3Synthetic Route of C11H14FNO).
4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Synthetic Route of C11H14FNO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem