Rowley, Michael et al. published their research in Journal of Medicinal Chemistry in 2001 | CAS: 50606-58-1

1-Benzylpiperidin-3-one hydrochloride (cas: 50606-58-1) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Recommanded Product: 1-Benzylpiperidin-3-one hydrochloride

3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT2A receptor antagonists was written by Rowley, Michael;Hallett, David J.;Goodacre, Simon;Moyes, Christopher;Crawforth, James;Sparey, Timothy J.;Patel, Smita;Marwood, Rose;Patel, Shil;Thomas, Steven;Hitzel, Laure;O’Connor, Desmond;Szeto, Nicola;Castro, Jose L.;Hutson, Peter H.;MacLeod, Angus M.. And the article was included in Journal of Medicinal Chemistry in 2001.Recommanded Product: 1-Benzylpiperidin-3-one hydrochloride This article mentions the following:

The development of very high affinity, selective, and bioavailable h5-HT2A receptor antagonists is described. By investigation of the optimal position for the basic nitrogen in a series of 2-phenyl-3-piperidylindoles, it was found that with the basic nitrogen at the 3-position of the piperidine it was not necessary to further substitute the piperidine in order to obtain good binding at h5-HT2A receptors. This meant the compounds no longer had high affinity at the IKr potassium channel, an issue with previous series of 2-aryl-3-(4-piperidyl)indoles. Improvements could be made to oral bioavailability in this series by reduction of the pKa of the basic nitrogen, by adding a fluorine atom to the piperidine ring, leading to 3-(4-fluoropiperidin-3-yl)-2-phenyl-1H-indole (17). Metabolic studies with this compound identified oxidation at the 6-position of the indole as a major route in vitro and in vivo in rats. Blocking this position with a fluorine atom led to 6-fluoro-3-(4-fluoropiperidin-3-yl)-2-phenyl-1H-indole (22), an antagonist with 0.06 nM affinity for h5-HT2A receptors, with bioavailability of 80% and half-life of 12 h in rats. In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidin-3-one hydrochloride (cas: 50606-58-1Recommanded Product: 1-Benzylpiperidin-3-one hydrochloride).

1-Benzylpiperidin-3-one hydrochloride (cas: 50606-58-1) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Recommanded Product: 1-Benzylpiperidin-3-one hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem