Quinazoline derivatives by cyclodehydrogenation of N-(2-substituted aryl)piperidines was written by Mohrle, H.;Jeandree, M.. And the article was included in Zeitschrift fuer Naturforschung, B: Chemical Sciences in 1999.SDS of cas: 4045-30-1 This article mentions the following:
Dehydrogenation of 2-piperidin-1-ylbenzamides using Hg(II)-EDTA yielded the corresponding quinazolinones. Increasing size of the 4-substituent in the piperidine decreased the oxidation rate and the product yield. 2-Piperidin-1-ylbenzaldehyde oximes showed a different behavior. While 2-piperidin-1-ylbenzaldehyde oxime with Hg(II)-EDTA in water produced 2-(2-oxopiperidin-1-yl)benzaldehyde oxime in quant. yield, with 4-substituted piperidines not only a lower reaction rate but also an altered product pattern was observed The double dehydrogenation to lactams was reduced and cyclic nitrones, formed by two electron withdrawal, became dominant. The mechanism of the reactions is discussed. In the experiment, the researchers used many compounds, for example, 4,4-Dimethylpiperidine (cas: 4045-30-1SDS of cas: 4045-30-1).
4,4-Dimethylpiperidine (cas: 4045-30-1) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.SDS of cas: 4045-30-1
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem