Synthesis and pharmacological evaluation of some 6-substituted 7-methyl-1,4-dioxa-7-azaspiro[4.5]decanes as potential dopamine agonists was written by Brubaker, Abram N.;Colley, Matt Jr.. And the article was included in Journal of Medicinal Chemistry in 1986.Related Products of 50606-58-1 This article mentions the following:
Title spiro compounds I (R = Ph, 3- or 4-indolyl) were synthesized via alkylation of enamine II. The spirodecane derivatives were evaluated for in vivo central and peripheral dopamine agonist activity. None of the compounds displayed central nervous system activity; however, the 4-indolylmethyl analog exhibited potent dopamine agonist activity in the cat cardioaccelerator nerve assay and possesses an ID50 of 0.095 μmol/kg compared to apomorphine, which possesses and ID50 of 0.0348 μmol/kg in the same assay. In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidin-3-one hydrochloride (cas: 50606-58-1Related Products of 50606-58-1).
1-Benzylpiperidin-3-one hydrochloride (cas: 50606-58-1) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Related Products of 50606-58-1
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem