Bao, Zongbi et al. published their research in Journal of Liquid Chromatography & Related Technologies in 2008 | CAS: 109887-53-8

((3R,4S)-rel-4-(4-Fluorophenyl)-1-methylpiperidin-3-yl)methanol (cas: 109887-53-8) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Category: piperidines

Enantioseparation of paroxetine precursors by HPLC on amylose and tartardiamide-based chiral stationary phases was written by Bao, Zongbi;Su, Baogen;Yang, Yiwen;Ren, Qilong. And the article was included in Journal of Liquid Chromatography & Related Technologies in 2008.Category: piperidines This article mentions the following:

Two important precursors of antidepressant trans-(-)-paroxetine, i.e., trans-4-(4′-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine and trans-3- ethoxycarbonyl-4-(4′-fluorophenyl)-1-methylpiperidine-2,6-dione were directly separated by HPLC on Chiralpak AD-H and Kromasil CHI-TBB columns. All the experiments were conducted in the normal phase mode. The mobile phases were mixtures of n-hexane and alc. modifiers including ethanol, 2-propanol, and 1-propanol, with or without addition of diethylamine. Excellent separation was obtained for both enantiomers. Effects and content of polar alc. modifiers on enantioseparation was studied. An unusual retention behavior was observed, i.e., the retention of enantiomers increased when the alc. modifier was changed from 2-propanol to ethanol. The elution orders of the enantiomers on both columns were examined The thermodn. parameters obtained from van’t Hoff plots were all neg., which indicated that the chiral separation were enthalpically driven. In the experiment, the researchers used many compounds, for example, ((3R,4S)-rel-4-(4-Fluorophenyl)-1-methylpiperidin-3-yl)methanol (cas: 109887-53-8Category: piperidines).

((3R,4S)-rel-4-(4-Fluorophenyl)-1-methylpiperidin-3-yl)methanol (cas: 109887-53-8) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem