Exploration of a New Type of Antimalarial Compounds Based on Febrifugine was written by Kikuchi, Haruhisa;Yamamoto, Keisuke;Horoiwa, Seiko;Hirai, Shingo;Kasahara, Ryota;Hariguchi, Norimitsu;Matsumoto, Makoto;Oshima, Yoshiteru. And the article was included in Journal of Medicinal Chemistry in 2006.SDS of cas: 95798-22-4 This article mentions the following:
Febrifugine (I), a quinazoline alkaloid, isolated from Dichroa febrifuga roots, shows powerful antimalarial activity against Plasmodium falciparum. The use of I as an antimalarial drug has been precluded because of side effects, such as diarrhea, vomiting, and liver toxicity. However, the potent antimalarial activity of I has stimulated medicinal chemists to pursue compounds derived from I, which may be valuable leads for novel drugs. In this study, we synthesized a new series of febrifugine derivatives formed by structural modifications at (i) the quinazoline ring, (ii) the linker, or (iii) the piperidine ring. Then, we evaluated their antimalarial activities. Thienopyrimidine analog II exhibited a potent antimalarial activity and a high therapeutic selectivity both in vitro and in vivo, suggesting that II is a good antimalarial candidate. In the experiment, the researchers used many compounds, for example, Benzyl 3-hydroxypiperidine-1-carboxylate (cas: 95798-22-4SDS of cas: 95798-22-4).
Benzyl 3-hydroxypiperidine-1-carboxylate (cas: 95798-22-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.SDS of cas: 95798-22-4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem