Lewis, Richard T. et al. published their research in Journal of Medicinal Chemistry in 2012 | CAS: 892493-65-1

tert-Butyl piperidine-4-carboxylate hydrochloride (cas: 892493-65-1) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.SDS of cas: 892493-65-1

The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer was written by Lewis, Richard T.;Bode, Christiane M.;Choquette, Deborah M.;Potashman, Michele;Romero, Karina;Stellwagen, John C.;Teffera, Yohannes;Moore, Earl;Whittington, Douglas A.;Chen, Hao;Epstein, Linda F.;Emkey, Renee;Andrews, Paul S.;Yu, Violeta L.;Saffran, Douglas C.;Xu, Man;Drew, Allison;Merkel, Patricia;Szilvassy, Steven;Brake, Rachael L.. And the article was included in Journal of Medicinal Chemistry in 2012.SDS of cas: 892493-65-1 This article mentions the following:

A class of 2-acyliminobenzimidazoles has been developed as potent and selective inhibitors of anaplastic lymphoma kinase (ALK). Structure based design facilitated the rapid development of structure-activity relationships (SAR) and the optimization of kinase selectivity. Introduction of an optimally placed polar substituent was key to solving issues of metabolic stability and led to the development of potent, selective, orally bioavailable ALK inhibitors. Compound I [Ar = 3,5-F2Ph] achieved substantial tumor regression in an NPM-ALK driven murine tumor xenograft model when dosed qd. Compound I [Ar = 3,5-F2Ph, 4-FPh] show favorable potency and PK characteristics in preclin. species indicative of suitability for further development. In the experiment, the researchers used many compounds, for example, tert-Butyl piperidine-4-carboxylate hydrochloride (cas: 892493-65-1SDS of cas: 892493-65-1).

tert-Butyl piperidine-4-carboxylate hydrochloride (cas: 892493-65-1) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.SDS of cas: 892493-65-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem