Design, synthesis and biological activity of N-(amino)piperazine-containing benzothiazinones against Mycobacterium tuberculosis was written by Wang, Apeng;Xu, Shijie;Chai, Yun;Xia, Guimin;Wang, Bin;Lv, Kai;Ma, Chao;Wang, Dan;Wang, Aoyu;Qin, Xiaoyu;Liu, Mingliang;Lu, Yu. And the article was included in European Journal of Medicinal Chemistry in 2021.Computed Properties of C9H19N3O2 This article mentions the following:
A series of novel benzothiazinone derivatives containing a N-(amino)piperazine moiety I (R1 = H, Me, iso-Bu, etc.; R2 = cyclohexyl, 4-(methoxyimino)cyclohexyl, 4-F3CC6H4, etc.), II (R = cyclohexylmethyl, 4-trifluoromethoxybenzyl, cyclohexanecarbonyl, pyridin-4-ylmethyl) based on the structure of WAP-1902 discovered, were designed and synthesized as new anti-TB agents. Many of the compounds exhibited excellent in vitro activity against both drug-sensitive MTB strain H37Rv and multidrug-resistant clin. isolates (MIC: < 0.016娓璯/mL), and good safety index (CC50: >64娓璯/mL). Especially compound I (R1 = Me; R2 = 4-(methoxyimino)cyclohexyl) displayed low hERG cardiac toxicity and acceptable oral pharmacokinetic profiles, indicating its promising potential to be a lead compound for future antitubercular drug discovery. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-aminopiperazine-1-carboxylate (cas: 118753-66-5Computed Properties of C9H19N3O2).
tert-Butyl 4-aminopiperazine-1-carboxylate (cas: 118753-66-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Computed Properties of C9H19N3O2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem