New xanthine derivatives with potent and long lasting anti-bronchoconstrictive activity was written by Regnier, Gilbert L.;Guillonneau, Claude G.;Duhault, Jacques L.;Tisserand, Francoise P.;Saint-Romas, Guy;Holstorp, Sophie M.. And the article was included in European Journal of Medicinal Chemistry in 1987.Synthetic Route of C7H13NO2 This article mentions the following:
Twenty-nine new derivatives of 8-aminoalkyl-substituted xanthine [e.g. I, R1 = H, Me, Et; R2 = Me, iso-Pr, Ph, etc.; R3 = H, Me, 2,3-dihydroxypropyl, etc.; R4 = H or F; and X = CH(OH)CH2, (CH2)n; n = 1-3] were synthesized. All I demonstrated a potent anti-bronochoconstrictive effect in the guinea pig and some had a very long duration of action (> 48h). II was selected for clin. trials in asthmatic patients because of its long duration of action, its lack of central nervous system-stimulating effects and its inhibiting action on mast cell degranulation and phosphodiesterse activity. Structure-activity relationships are discussed. In the experiment, the researchers used many compounds, for example, 1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1Synthetic Route of C7H13NO2).
1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Synthetic Route of C7H13NO2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem