Synthesis of aryl (alkyl) ketones of the piperidine series was written by Kuroyan, R. A.;Markosyan, A. I.;Snkhchyan, G. M.;Vartanyan, S. A.. And the article was included in Armyanskii Khimicheskii Zhurnal in 1983.COA of Formula: C13H16N2 This article mentions the following:
Alkyl (aryl) piperidinyl ketones I [R = PhCH2, R1 = H, R2 = C1-5 n-alkyl, (un)substituted Ph, PhCH2; R = R1 = Me, R2 = (un)substituted Ph, PhCH2] were prepared from the corresponding piperidinecarboxaldehyde by oximation, dehydration to the nitrile and Grignard reaction with R2X (X = undefined halo). In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidine-4-carbonitrile (cas: 62718-31-4COA of Formula: C13H16N2).
1-Benzylpiperidine-4-carbonitrile (cas: 62718-31-4) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.COA of Formula: C13H16N2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem