Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective α-sulfone hydroxamates was written by Kolodziej, Stephen A.;Hockerman, Susan L.;Boehm, Terri L.;Carroll, Jeffery N.;DeCrescenzo, Gary A.;McDonald, Joseph J.;Mischke, Debbie A.;Munie, Grace E.;Fletcher, Theresa R.;Rico, Joseph G.;Stehle, Nathan W.;Swearingen, Craig;Becker, Daniel P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Electric Literature of C12H17NO This article mentions the following:
A series of Ph piperidine α-sulfone hydroxamate derivatives, e.g., I, has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing of MMP-1 and MMP-14 (MT1-MMP) and exhibit oral bioavailability in rats. In the experiment, the researchers used many compounds, for example, 4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8Electric Literature of C12H17NO).
4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Electric Literature of C12H17NO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem