Meng, Depei et al. published their research in Cell Reports Physical Science in 2021 | CAS: 651057-01-1

1-(Methylsulfonyl)piperidin-4-amine hydrochloride (cas: 651057-01-1) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Related Products of 651057-01-1

A radical chlorodifluoromethylation protocol for late-stage difluoromethylation and its application to an oncology candidate was written by Meng, Depei;Li, Lingchun;Brown, Adam;Desrosiers, Jean-Nicolas;Duan, Shengquan;Hayward, Cheryl M.;He, Zhengbiao;Hu, Jinbo;Makowski, Teresa;Maloney, Mark;Monfette, Sebastien;Perfect, Hahdi;Piper, Jared L.;Zhou, Min;Widlicka, Daniel W.. And the article was included in Cell Reports Physical Science in 2021.Related Products of 651057-01-1 This article mentions the following:

An efficient radical chlorodifluoromethylation protocol with sodium chlorodifluoromethanesulfinate, which is complementary to the existing late-stage difluoromethylation strategies has been described. CF2Cl radical is a suitable surrogate for accessing the CF2H group while possessing completely different electronic properties compared to the CF2H radical. This method is chemoselective and regioselective for the chlorodifluoromethylation of (hetero)arenes RH [R = 2,4,6-trimethylphenyl, 2,3-dihydro-1,4-benzodioxin-5-yl, 4-oxo-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-3-yl, etc.] and electron-rich alkenes R1C(=CH2)OAc (R1 = Ph, 2-naphthyl, 2-thienyl, etc.) and shows good functionality, tolerance, and generality on scope. The preparation of the sodium chlorodifluoromethanesulfinate is thoroughly investigated and can be scaled up to hundreds of kilograms. The method is successfully implemented on the synthesis of an oncol. candidate compound I. In the experiment, the researchers used many compounds, for example, 1-(Methylsulfonyl)piperidin-4-amine hydrochloride (cas: 651057-01-1Related Products of 651057-01-1).

1-(Methylsulfonyl)piperidin-4-amine hydrochloride (cas: 651057-01-1) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Related Products of 651057-01-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem