Convergent and stereoselective method for the synthesis of acyclic α-chloroenamides was written by Surgenor, Richard R.;Grote, Andrea C.;McGeough, Catherine;Narayanan, Arjun;Wang, Wenyu;Collier, Philip N.. And the article was included in Journal of Organic Chemistry in 2020.Quality Control of 1-(Methylsulfonyl)piperidin-4-amine hydrochloride This article mentions the following:
A direct, stereocontrolled synthesis of acyclic α-chloroenamides is presented. Our methodol. showed good yields and substrate scope. Mechanistic insights are provided that account for the high levels of stereoselectivity reported. Subsequent synthetic manipulation of the α-chloroenamides provides direct entry to polyfunctionalized acyclic enamides, compounds of wide use in organic chem. and the pharmaceutical industry. In the experiment, the researchers used many compounds, for example, 1-(Methylsulfonyl)piperidin-4-amine hydrochloride (cas: 651057-01-1Quality Control of 1-(Methylsulfonyl)piperidin-4-amine hydrochloride).
1-(Methylsulfonyl)piperidin-4-amine hydrochloride (cas: 651057-01-1) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Quality Control of 1-(Methylsulfonyl)piperidin-4-amine hydrochloride
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem