Synthesis of substituted 4-azaisoindoles – New tacrine analogues was written by Bekolo, Henri;Kirsch, Gilbert. And the article was included in Canadian Journal of Chemistry in 2007.Safety of 1-Tosylpiperidin-4-one This article mentions the following:
The regioselective Friedlaender reaction of 3-amino-4-cyanopyrroles with a series of cyclic ketones has enabled the first reported synthesis of substituted 4-azaisoindoles, e.g. I. Structurally, this new class of compounds stands for the first reported 4-azaisoindole tacrine analogs. A reaction mechanism for the formation of the reported 4-azaisoindoles is proposed. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Safety of 1-Tosylpiperidin-4-one).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Safety of 1-Tosylpiperidin-4-one
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem