Catalytic reductive ring opening of epoxides enabled by zirconocene and photoredox catalysis was written by Aida, Kazuhiro;Hirao, Marina;Funabashi, Aiko;Sugimura, Natsuhiko;Ota, Eisuke;Yamaguchi, Junichiro. And the article was included in Chem in 2022.Name: 1-Boc-4-Hydroxy-4-methylpiperidine This article mentions the following:
Herein, an unprecedented zirconocene-catalyzed ring opening of epoxides enabled by photoredox catalysis is reported. Compared with the conventional ring-opening methods, the present protocol exhibits reverse regioselectivity to afford more substituted alcs. via putative less-stable radicals. This reaction is remarkably mild and smoothly cleaves C-O bonds in mols. with a variety of functional groups, including natural products. The finding that changes the metal center in metallocene influences the energy profile of ring opening is a significant advance and provides a new perspective in radical chem. with group IV metals. In the experiment, the researchers used many compounds, for example, 1-Boc-4-Hydroxy-4-methylpiperidine (cas: 406235-30-1Name: 1-Boc-4-Hydroxy-4-methylpiperidine).
1-Boc-4-Hydroxy-4-methylpiperidine (cas: 406235-30-1) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Name: 1-Boc-4-Hydroxy-4-methylpiperidine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem