Dearomative Cyclopropanation of Naphthols via Cyclopropene Ring-Opening was written by Baker, Rachel J.;Ching, Justin;Hou, Teh Ren;Franzoni, Ivan;Lautens, Mark. And the article was included in Angewandte Chemie, International Edition in 2022.COA of Formula: C12H15NO3S This article mentions the following:
The dearomatization of 2-naphthols represents a simple method for the construction of complex 3D structures from simple planar starting materials. A cyclopropanation of 2-naphthols that proceeds via cyclopropene ring-opening using rhodium and acid catalysis under mild conditions is described. The vinyl cyclopropane mols. were formed with high chemoselectivity and scalability, which could be further functionalized at different sites. Both computational and exptl. evidence were used to elucidate the reaction mechanism. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9COA of Formula: C12H15NO3S).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.COA of Formula: C12H15NO3S
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem