Synthesis, characterization and antimicrobial activity of substituted tricyclic compounds: 5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidines was written by Mittal, Manish;Sarode, Suraj M.;Vidyasagar, G.. And the article was included in International Journal of Pharma and Bio Sciences in 2011.Formula: C12H15NO3S This article mentions the following:
7-(Arylsulfonyl)-N-aryl-5,6,7,8-tetrahydropyrido[4,3′:4,5]thieno[2,3-d]pyrimidin-4-amines were synthesized from 7-(arylsulfonyl)-4-chloro-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidines using piperidin-4-one.HCl and arenesulfonyl chloride as the starting material. All the synthesized products were evaluated for antibacterial activity against B. subtilis, E. coli, K. pneumoniae, and S. aureus as well as for antifungal activity against A. niger, A. flavus, F. oxysporum, and T. viride. Most of the synthesized compounds exhibited antibacterial and antifungal activity. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Formula: C12H15NO3S).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Formula: C12H15NO3S
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem