Cyano phosphate: an efficient intermediate for the chemoselective conversion of carbonyl compounds to nitriles was written by Yoneda, Ryuji;Harusawa, Shinya;Kurihara, Takushi. And the article was included in Journal of Organic Chemistry in 1991.Application In Synthesis of 1-Benzylpiperidine-4-carbonitrile This article mentions the following:
Cyanohydrin di-Et phosphates, readily obtained from various ketones and aldehydes by reaction with di-Et phosphorocyanidate and lithium cyanide, reacted chemoselectively with SmI2 in THF to give the corresponding nitriles in excellent yields. This method was also found applicable to α,β-unsaturated carbonyl compounds via cyano phosphates to give β,γ-unsaturated nitriles, not obtainable by standard methods, without isomerization of the double bonds. In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidine-4-carbonitrile (cas: 62718-31-4Application In Synthesis of 1-Benzylpiperidine-4-carbonitrile).
1-Benzylpiperidine-4-carbonitrile (cas: 62718-31-4) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Application In Synthesis of 1-Benzylpiperidine-4-carbonitrile
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem