Synthesis of hetero-aryl-piperazines and hetero-aryl-bipiperidines with a restricted side chain and their affinities for 5-HT1A receptor was written by Yoo, Kyung Ho;Choi, Hyun Sik;Kim, Dong Chan;Shin, Kye Jung;Kim, Dong Jin;Song, Yun Seon;Jin, Changbae. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2003.Reference of 33439-27-9 This article mentions the following:
Heteroarylpiperazine and heteroarylbipiperidine derivatives, bearing a 4-piperidine ring instead of an alkylamino side chain to give the semi-rigidity, were prepared and evaluated for their abilities to displace [3H]-8-OH-DPAT binding to the rat hippocampal synaptic membranes. These compounds showed low to moderate affinities for 5-HT1A receptor, with Ki values ranging from 6912 nM to 232 nM. Of these compounds, I and II exhibited the best affinities for 5-HT1A receptor with Ki values of 232 nM and 338 nM, resp. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Reference of 33439-27-9).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Reference of 33439-27-9
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem