Heteroatom-Directed Alkylcyanation of Alkynes was written by Nakao, Yoshiaki;Yada, Akira;Hiyama, Tamejiro. And the article was included in Journal of the American Chemical Society in 2010.HPLC of Formula: 62718-31-4 This article mentions the following:
Alkanenitriles having a heteroatom such as nitrogen, oxygen, and sulfur at the γ-position add across alkynes stereo- and regioselectively by nickel/Lewis acid catalysis to give highly substituted acrylonitriles. The heteroatom functionalities likely coordinate to the nickel center to make oxidative addition of the C-CN bonds of the alkyl cyanides kinetically favorable, forming a five-membered nickelacycle intermediate and, thus, preventing β-hydride elimination to allow the alkylcyanation reaction. In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidine-4-carbonitrile (cas: 62718-31-4HPLC of Formula: 62718-31-4).
1-Benzylpiperidine-4-carbonitrile (cas: 62718-31-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.HPLC of Formula: 62718-31-4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem