Wang, Shun et al. published their research in Journal of the American Chemical Society in 2020 | CAS: 33439-27-9

1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.SDS of cas: 33439-27-9

Umpolung Difunctionalization of Carbonyls via Visible-light Photoredox Catalytic Radical-Carbanion Relay was written by Wang, Shun;Cheng, Bei-Yi;Srsen, Matea;Koenig, Burkhard. And the article was included in Journal of the American Chemical Society in 2020.SDS of cas: 33439-27-9 This article mentions the following:

The combination of photoredox catalysis with the Wolff-Kishner (WK) reaction allows the difunctionalization of carbonyl groups by a radical-carbanion relay sequence (photo-Wolff-Kishner reaction). Photoredox initiated radical addition to N-sulfonylhydrazones yields α-functionalized carbanions following WK-type mechanism. With sulfur-centered radicals, the carbanions were further functionalized by reaction with electrophiles including CO2 and aldehydes to gave phenylthio aryl acetic acids R1C(SR2)(CO2H)R3 [R1 = 4-MeC6H3, 2-thienyl, Bn, etc.; R2 = Ph, cyclohexyl, CH2CH2Ph, etc.; R3 = H, Me, cyclopropyl, etc.] and phenylthio aryl ethanols (R3)(R4)C(SPh)CH(OH)R5 [R3 = H, Me; R4 = Ph, 2-thienyl, 4-PhC6H4; R5 = H, Et, Ph, etc.], whereas CF3 radical addition furnished a wide range of gem-difluoroalkenes R6R7C=CF2 [R6 = Ph, CH2C(O)NHPh, 4-PhC6H4CH2; R7 = H, Me, Bn, etc.; R6R7 = CH2N(Ts)CH2, CH2CH2N(Ts)CH2CH2, CH2CH2N(Boc)CH2CH2, CH2CH2CH(t-Bu)CH2CH2, (CH2)11] through β-fluoride elimination of the generated α-CF3 carbanions. More than 80 substrate examples demonstrated the broad applicability of this reaction sequence. A series of investigations including radical inhibition, deuterium labeling, fluorescence quenching, cyclic voltammetry and control experiments support the proposed radical-carbanion relay mechanism. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9SDS of cas: 33439-27-9).

1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.SDS of cas: 33439-27-9

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem