1-Hetera-4-cyclohexanone system. Proton and carbon-13 magnetic resonance, transannular effects, and conformational analysis was written by Hirsch, Jerry A.;Havinga, E.. And the article was included in Journal of Organic Chemistry in 1976.Product Details of 33439-27-9 This article mentions the following:
1H NMR and 13C NMR were used to study ring conformation in a series of 1-hetera-4-cyclohexanones. Comparison of the 13C NMR data with that from a series of 1-heteracyclohexanes and from acyclic analogs indicated that the effects α and β to the heteroatom groups in the 1-hetera-4-cyclohexanones are proportional to the effects in the same positions in the 1-heteracyclohexanes except for cyclohexane-1,4-dione (and therefore indicate chair conformations), that additivity relationships from the 1-heteracyclohexanes may be used as indications of chair or twist conformations in 1,4-diheteracyclohexanes and 1-hetera-4-cyclohexanones, and that upfield carbonyl shifts in 1-hetera-4-cyclohexanones and related systems do not contain transannular electron-transfer components. Previous suggestions that upfield carbonyl shifts of ∼10 ppm or less may be used to indicate transannular electron donation were refuted. An ordering of heteroatom group effects was presented based on 13C NMR α shifts in these cyclic systems. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Product Details of 33439-27-9).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Product Details of 33439-27-9
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem