Romeo, Giuseppe et al. published their research in Journal of Medicinal Chemistry in 2003 | CAS: 58333-75-8

4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Recommanded Product: 58333-75-8

New Pyrimido[5,4-b]indoles as Ligands for α1-Adrenoceptor Subtypes was written by Romeo, Giuseppe;Materia, Luisa;Manetti, Fabrizio;Cagnotto, Alfredo;Mennini, Tiziana;Nicoletti, Ferdinando;Botta, Maurizio;Russo, Filippo;Minneman, Kenneth P.. And the article was included in Journal of Medicinal Chemistry in 2003.Recommanded Product: 58333-75-8 This article mentions the following:

Tricyclic 5H-pyrimido[5,4-b]indoles I (R1 = H, Me, Et; n = 2, 3; R2 = 2-MeO, 2-EtO, 4-Me2CH, 4-Me3C) and II (R3 = NCCH2, Me2CH, Bu, Me3C, EtCHMe, cyclohexyl) bearing a piperazine moiety connected through an alkyl chain were designed as structural analogs of the α1-AR ligand RN5. I and II were synthesized and tested in binding assays on human α1A-AR, α1B-AR, and α1D-AR subtypes expressed in HEK293 cells, with many of the new mols. showing a preferential affinity for the α1D-AR subtype. Some compounds, including II (R3 = Me2CH, Me3C), displayed substantial α1D-AR selectivity with respect to α1A-AR, α1B-AR, serotonergic 5-HT1A, 5-HT1B, 5-HT2A, and dopaminergic D1 and D2 receptors. Two conformationally rigid analogs of RN5, useful for studying the architecture of the receptor/ligand complex, were also prepared and tested. A subset of the new compounds was then used to evolve a preliminary pharmacophore model for α1D-AR antagonists, based on a more generalized model developed for α1-AR antagonists. This new model rationalized the relationships between structural properties and biol. data of the pyrimido[5,4-b]indole compounds, as well as other compounds In the experiment, the researchers used many compounds, for example, 4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8Recommanded Product: 58333-75-8).

4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Recommanded Product: 58333-75-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem