Kumata, Katsushi et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2017 | CAS: 58333-75-8

4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Product Details of 58333-75-8

Synthesis and in vitro evaluation of three novel radiotracers for imaging of metabotropic glutamate receptor subtype 2 in rat brain was written by Kumata, Katsushi;Yamasaki, Tomoteru;Hatori, Akiko;Zhang, Yiding;Mori, Wakana;Fujinaga, Masayuki;Xie, Lin;Okubo, Takayuki;Nengaki, Nobuki;Zhang, Ming-Rong. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Product Details of 58333-75-8 This article mentions the following:

The purpose of this study was to develop three new radiotracers, 1-(cyclopropylmethyl)-4-([11C/18F]substituted-phenyl)piperidin-1-yl-2-oxo-1,2-dihydropyridine-3-carbonitrile I [R = 2-O11CH3 (II), 3-O11CH3 (III), 2-OCH2CH218F (IV)], and to examine their specific bindings with metabotropic glutamate receptor subtype 2 (mGluR2) in rat brain sections by using in vitro autoradiog. These compounds were found to possess potent in vitro binding affinities (Ki: 8.0-34.1 nM) for mGluR2 in rat brain homogenate. II, III, and IV were synthesized by [11C/18F]alkylation of the corresponding phenol precursors with [11C]methyl iodide or [18F]fluoroethyl bromide with >98% radiochem. purity and 80-130 GBq/μmol specific activity at the end of synthesis. In vitro autoradiog. indicated that these radiotracers showed heterogeneous specific bindings in mGluR2-rich brain regions, such as the cerebral cortex, striatum, hippocampus, and granular layer of the cerebellum. In the experiment, the researchers used many compounds, for example, 4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8Product Details of 58333-75-8).

4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Product Details of 58333-75-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem