Electrochemical Deprotection of para-Methoxybenzyl Ethers in a Flow Electrolysis Cell was written by Green, Robert A.;Jolley, Katherine E.;Al-Hadedi, Azzam A. M.;Pletcher, Derek;Harrowven, David C.;De Frutos, Oscar;Mateos, Carlos;Klauber, David J.;Rincon, Juan A.;Brown, Richard C. D.. And the article was included in Organic Letters in 2017.Related Products of 33439-27-9 This article mentions the following:
Electrochem. deprotection of p-methoxybenzyl (PMB) ethers was performed in an undivided electrochem. flow reactor in MeOH solution, leading to the unmasked alc. and p-methoxybenzaldehyde di-Me acetal as a byproduct. The electrochem. method removes the need for chem. oxidants, and added electrolyte (BF4NEt4) can be recovered and reused. The method was applied to 17 substrates with high conversions in a single pass, yields up to 92%, and up to 7.5 g h-1 productivity. The PMB protecting group was also selectively removed in the presence of some other common alc. protecting groups. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Related Products of 33439-27-9).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Related Products of 33439-27-9
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem