Synthesis and bioactivity of new amides and ureas from 2-amino-5-(1-R-phenylsulfonyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridines was written by Pavlova, A. S.;Yakunina, I. E.;Shumskii, A. N.;Shakhkel’dyan, I. V.;Atroshchenko, Yu. M.;Kobrakov, K. I.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2010.Application of 33439-27-9 This article mentions the following:
Hantzsch cyclization of N-(arylsulfonyl)-3-bromo-5-piperidinones (aryl = R1 = Ph, 4-MeC6H4, 4-MeOC6H4), available in 2 steps from 4-piperidinone hydrochloride and arylsulfonyl chlorides, with thiourea afforded the corresponding tetrahydrothiazolo[5,4-c]pyridines I (R2 = H) in 60-65% yields. Subsequent reactions of the latter with carboxylic acids in the presence of carbonyldiimidazole or with isocyanates gave the combinatorial libraries of amides I (R2 = n-PrCO, PhCO, etc.) or ureas I (R2 = 2-EtOC6H4NHCO, 3,4-Me2C6H4NHCO, etc.), resp. The antimicrobial activity of some amides and ureas towards Escherichia coli and Agrobacterium tumefaciens was evaluated. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Application of 33439-27-9).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Application of 33439-27-9
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem