Substitution of α-azido ethers with Grignard reagents and its use in combinatorial chemistry was written by Baruah, Mukulesh;Bols, Mikael. And the article was included in Journal of the Chemical Society, Perkin Transactions 1 in 2002.COA of Formula: C7H13NO2 This article mentions the following:
α-Azidobenzyl ethers reacted with alkyl or aryl Grignard reagents in toluene to produce α-alkylbenzyl or diarylmethyl ethers in 82-94% yield. α-Azidobenzyl ethers also reacted with multicomponent Grignard reagents to produce libraries of α-alkylbenzyl ethers. In the experiment, the researchers used many compounds, for example, 1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1COA of Formula: C7H13NO2).
1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.COA of Formula: C7H13NO2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem