A Practical Source of Chlorodifluoromethyl Radicals. Convergent Routes to gem-Difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols was written by Salomon, Pierre;Zard, Samir Z.. And the article was included in Organic Letters in 2014.Application of 33439-27-9 This article mentions the following:
The preparation of O-octadecyl-S-chlorodifluoromethyl xanthate ClF2CS(C:S)OC18H37 (I) from chlorodifluoroacetic acid and its use as a convenient source of chlorodifluoromethyl radicals is described. This reagent may be used to access gem-difluoroalkenes and -dienes, as well as (2,2-difluoroethyl)indolines, -indoles, and -naphthols [e.g., I + 1-allyl-2,3-dimethoxybenzene followed by reductive removal of xanthate group → II; dehydrochlorination of II → III]. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Application of 33439-27-9).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application of 33439-27-9
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem