Bulletin of the Chemical Society of Japan published new progress about 72002-30-3. 72002-30-3 belongs to piperidines, auxiliary class Piperidine,Chiral,Carboxylic acid,Amide, name is (R)-6-Oxopiperidine-2-carboxylic acid, and the molecular formula is C6H9NO3, HPLC of Formula: 72002-30-3.
Hashimoto, Tadashi published the artcileSyntheses and biological activities of substance P analogs containing L– and D-homoglutamine and L– and D-pyrohomoglutamic acid at positions 5 and 6, HPLC of Formula: 72002-30-3, the publication is Bulletin of the Chemical Society of Japan (1987), 60(3), 1207-9, database is CAplus.
Six title substance P (SP) analogs were prepared by the solid-phase method on a benzylhydrylamine resin. The smooth muscle contractile activities of these analogs were compared with the activity of SP on isolated guinea pig ileum and trachea. The potency of [D-Hgn5,Hgn6]-SP (Hgn = homoglutamine residue) was as high as that of SP in the guinea pig ileum assay. The replacements of both Gln residues at positions 5 and 6 with the Hgn-D-Hgn sequence brought a drastic decrease in activity. The D-pyroHgu-Hgn-Phe-Phe-Gly-Leu-Met-NH2 (pyroHgu = pyrohomoglutamic acid) analog possessed the highest potency among the 6 analogs.
Bulletin of the Chemical Society of Japan published new progress about 72002-30-3. 72002-30-3 belongs to piperidines, auxiliary class Piperidine,Chiral,Carboxylic acid,Amide, name is (R)-6-Oxopiperidine-2-carboxylic acid, and the molecular formula is C6H9NO3, HPLC of Formula: 72002-30-3.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem