Abood, L. G. published the artcileA new class of psychotogenic substances, Computed Properties of 13444-24-1, the publication is Mol. Mental Health, Papers Sci. Congrs. Brain Research Foundation; New York and Chicago (1959), 69-76, database is CAplus.
Piperidyl benzilate derivatives of formula CH2(CH2)2NACH2CHOCOCBRC6H5 were tested on humans for psychotogenic effects. With A, B, and R, resp., Et, OH, cyclohexyl; Et, OH, cyclopentyl; Me, OH, Ph; Me, OH, 2-thienyl; Et, OH, Ph; Et, OH, Pr; Et, H, Ph; 2Me, OH, Ph; and Et and Me, OH, Ph. With R as some cycloalkyl group the psychotogenic potency is greater than with phenyl substitution. If R is a thienyl group, the duration of the response is considerably less, although the psychotogenic effectiveness is about the same. The 4-piperidine linked isomers are less active than the 3 isomers. If A is Me, the maximum potency is obtained; with higher aliphatic chains the potency decreases. Replacement of H in the benzilic acid moiety by OH leads to a disappearance of potency. The same effect occurs if the piperidine N is made quaternary. No correlation between psychotogenic and anticholinergic potency was found.
Mol. Mental Health, Papers Sci. Congrs. Brain Research Foundation; New York and Chicago published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, Computed Properties of 13444-24-1.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem