Abood, L. G. published the artcileStructure-activity relationships of 3-piperidyl benzilates with psychotogenic properties, Related Products of piperidines, the publication is Archives Internationales de Pharmacodynamie et de Therapie (1959), 186-200, database is CAplus.
Correlation of pharmacol. and psychotogenic properties of compounds of structure CH2.CH2.CH2NA.CH2.CHOCOC(Ph)(B)(R) was attempted. In addition to auditory and visual hallucinations, mood changes, disorientation, hypochondriacal and paranoid delusions, and partial loss of contact were observed on administration of such compounds The most effective compound was N-methyl-3-piperidyl phenylcyclohexyl glycolate (I). Other materials studied included (given in order are A, B, and R): Me, OH, cyclohexyl (II); Et, OH, II; Et, OH, cyclopentyl; Me, OH, Ph; Me, OH, 2-thienyl; Et, OH, Ph; CH2CH2NMe2, OH, Ph; 1,2,2,6,6-pentamethyl (3-piperidyl isomer), OH, Ph; Me, OH, Ph; Et, OH, Pr; H, OH, Ph; Et, H, Ph; (CH3)2, OH, Ph; and (C2H5)CH3, OH, Ph. These compounds were potent anticholinergic agents, the best being the 2-thienyl compound Most compounds were antihistamines. Physostigmine counteracted anticholinergic effects but potentiated muscular ones. These compounds effectively blocked mydriasis, tachycardia, and hyperemia. Substitution of H for OH abolishes psychotogenic properties as does quaternization of the piperidyl ring. Replacement of Ph with II in compounds containing N-Me or N-Et enhances psychotogenic effects. Substitution of 2-thienyl for Ph diminishes reaction duration but increases anticholinergic and antihistaminic potencies. The psychotogenic properties do not correlate with toxicity, antispasmodic potency, of mydriasis.
Archives Internationales de Pharmacodynamie et de Therapie published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, Related Products of piperidines.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem