Abood, L. G. published the artcilePossible role of brain mitochondria in psychopharmacology, Application In Synthesis of 13444-24-1, the publication is Journal of Neuropsychiatry (1959), 92-5, database is CAplus.
cf. CA 53, 22487b. Experiments were performed on rat-brain mitochondria to determine the presence of cholinergic receptor sites. It was observed that the distribution of tritiated N-ethyl-3-piperidyl benzilate (JB-318) (I) was similar to that of acetylcholine in the cellular fractions of rat brain. The largest concentration was found in the mitochondria. It was concluded that the cholinergic receptor sites were in this fraction or granules associated with this fraction. The inhibition of a number of drugs upon the binding of I to mitochondria was chlorpromazine 80, 3-piperidyl benzilate (JB-305) and N,N’-piperazinodiethyl dibenzilate 50, hydroxyzine 44, and dinitrophenol 20%. It was suggested that if the receptor sites are confined to cytoplasmic particles, then the phenothiazine types of tranquilizers and the psycho-mimetic agents act at the mitochondrial level of the cell.
Journal of Neuropsychiatry published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, Application In Synthesis of 13444-24-1.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem