Teramoto, Hiroyoshi published the artcileDesign and synthesis of a piperidinone scaffold as an analgesic through kappa-opioid receptor: Structure-activity relationship study of matrine alkaloids, Recommanded Product: Piperidine-4-carboxamide, the publication is Chemical & Pharmaceutical Bulletin (2016), 64(5), 410-419, database is CAplus and MEDLINE.
The matrine-type alkaloid 4-dimethylamino-1-pentanoylpiperidine (I) has an antinociceptive effect through its impact on the κ-opioid receptor (KOR). Derivatives of I were synthesized by altering its amide and tertiary amine groups; and they were evaluated for their antinociceptive effects. The results indicated that the distance between these groups on I was optimal for the antinociceptive effect. The effects obtained with racemic compounds II [R = β-CH2Ph, α-CH2Ph, R1 = α-H, R2 = R3 = H; R = β-CH2Ph, α-CH2Ph, R1 = α-H, R2 = (CH2)4Me, R3 = H; R = H, R1 = α-H, β-H, R2 = H, R3 = β-CH2Ph; R = H, R1 = α-H, β-H, R2 = (CH2)4Me, R3 = β-CH2Ph] and (-)-II [R = β-CH2Ph, R1 = β-H, R2 = H, (CH2)4Me, R3 = H] indicated that the relative configuration of the 3- and 4-substituents influenced the effect mediated through the KOR.
Chemical & Pharmaceutical Bulletin published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C18H28B2O4, Recommanded Product: Piperidine-4-carboxamide.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem