Bogolubsky, Andrey V. published the artcileBis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas, Name: Piperidine-4-carboxamide, the publication is ACS Combinatorial Science (2014), 16(6), 303-308, database is CAplus and MEDLINE.
One-pot parallel synthesis of unsym. aliphatic ureas was achieved with bis(2,2,2-trifluoroethyl) carbonate. The procedure worked well for both the monosubstituted and functionalized alkylamines and required no special conditions (temperature control, order, or rate of addition). Thus, an acetonitrile solution of the first alkylamine, N,N-diisopropylethylamine, and bis(2,2,2-trifluoroethyl) carbonate was heated at 75 °C in a sealed tube for 2 h. After complete removal of bis(2,2,2-trifluoroethyl) carbonate and addition of DBU, the second alkylaminewas added to the crude trifluoroethyl carbamate to give the unsym. aliphatic urea. A library of 96 diverse ureas was easily synthesized.
ACS Combinatorial Science published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Name: Piperidine-4-carboxamide.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem